- 代谢与细胞工程导论(影印版国外生命科学优秀教材)
- - 作者：(阿根廷)科他萨|责编:谢灵玲//周辉
  - 出版社：科学
  - ISBN：9787030123640
  - 出版日期：2004/04/01
  - 页数：248
- 售价：39.2

内容大纲
本书阐述了将两大技术遗传分子生物学技术与发酵技术有机联系在一起，将各学科如微生物生理学、生物能学、热动力学和酶动力学、生物数学与生物化学、遗传学与分子生物学的方法整合协调，形成跨学科的方法，经过合理设计，以某种方式最大限度地利用微生物或细胞。内容包括：物质与能量平衡、细胞生长与代谢产物、生物过程动力学、植物细胞发育、细胞工程等等。
本书可作为生物工程、生物技术、生物医学工程等专业本科生、研究生教材，还可供生物工程技术人员以及相关科研人员参考。
作者介绍
目录
Preface
List of Abbreviations
Introduction
  Introductory Outlines
  Metabolic and Cellular Engineering in the Context of Bioprocess Engineering
  Tools for Metabolic and Cellular Engineering
  Engineering Cells for Specific Biotransformations
  Metabolic Areas that Have Been Subjected to MCE
  From DNA Sequence to Biological Function
  Temporal and Spatial Scaling in Cellular Processes
  Scaling in Microbial and Biochemical Systems
  Views of the Cell
  Black and Grey Boxes: Levels of Description of Metabolic Behavior in Microorganisms
  Transduction and Intracellular Signalling
  Self-organized Emergent Phenomena
  Homeodynamics and Coherence
Matter and Energy Balances
  Mass Balance
  General Formulation of Mass Balance
  Integral and Differential Mass Balances
  Growth Stoichiometry and Product Formation
  Biomass and Product Yields
  Electron Balance
  Theoretical Oxygen Demand
  Opening the Black Box Mass Balance as the Basis of Metabolic Flux Analysis
  Energy Balance
  Forms of Energy and Enthalpy
  An Introduction to Metabolic and Cellular Engineering Calorimetric Studies of Energy Metabolism
  Heat of Combustion
  An Energetic View of Microbial Metabolism
Cell Growth and Metabolite Production.Basic Concepts
  Microbial Growth under Steady and Balanced Conditions
  Microbial Energetics under Steady State Conditions
  Growth Kinetics under Steady State Conditions
  The Dilution Rate
  The Dilution Rate and Biomass Concentration
  The Dilution Rate and the Growth-limiting Substrate Concentration 87 Biomass and Growth-limiting Substrate Concentration at
the Steady State
  Growth as a Balance of Fluxes
  The Flux Coordination Hypothesis
  Toward a Rational Design of Cells
  Redirecting Central Metabolic Pathways under Kinetic or Thermodynamic Control
  Thermodynamic or Kinetic Control of Flux under Steady State Conditions
  Kinetic and Thermodynamic Limitations in Microbial Systems Case Studies
  Saccharomyces cerevisiae
  Escherichia coli
  Increasing Carbon Flow to Aromatic Biosynthesis in Escherichia coli
Methods of Quantitation of Cellular Processes Performance
  Stoichiometry of Growth: The Equivalence between Biochemical Stoichiometries and Physiological Parameters
  A General Formalism for Metabolic Flux Analysis

  A Comparison between Different Methods of MFA
  MFA Applied to Prokaryotic and Lower Eukaryotic Organisms
  MFA as Applied to Studying the Performance of Mammalian Cells in Culture
  Metabolic Fluxes during Balanced and Steady State Growth
  Bioenergetic and Physiological Studies in Batch and Continuous Cultures.Genetic or Epigenetic Redirection of Metabolic Flux
  Introduction of Heterologous Metabolic Pathways
  Metabolic Engineering of Lactic Acid Bacteria for Optimising Essential Flavour Compounds Production
  Metabolic Control Analysis
  Summation and connectivity theorems
  Control and Regulation
  The Control of Metabolites Concentration
  A Numerical Approach for Control Analysis of Metabolic Networks and Nonlinear Dynamics
  The TDA Approach as Applied to the Rational Design of Microorganisms: Increase of Ethanol Production in Yeast
  Phase I: Physiological， Metabolic and Bioenergetic Studies of Different Strains of S.cerevisiae
  Phase II: Metabolic Control Analysis and Metabolic Flux Analysis of the Strain under the Conditions Defined in Phase Ⅰ
  Phases III and IV: To Obtain a Recombinant Yeast Strain with an Increased Dose of PFK， and to Assay the Engineered
Strain in Chemostat Cultures under the Conditions Specified in Phase Ⅰ
  Appendix A
  A Simplified Mathematical Model to Illustrate the Matrix Method of MCA
  Appendix B
  Conditions for Parameter Optimisation and Simulation of the Mathematical Model of Glycolysis
Dynamic Aspects of Bioprocess Behavior
  Transient and Oscillatory States of Continuous Culture
  Mathematical Model Building
  Transfer-Function Analysis and Transient-Response Techniques
  Theoretical Transient Response and Approach to Steady State
  Transient Responses of Microbial Cultures to Perturbations of the Steady State
  Dilution Rate
  Feed Substrate Concentration
  Growth with Two Substrates
  Temperature
  Dissolved Oxygen
  The Meaning of Steady State Performance in Chemostat Culture
  Oscillatory Phenomena in Continuous Cultures
  1.Oscillations as a Consequence of Equipment Artifacts
  2.Oscillations Derived from Feedback Between Cells and Environmental Parameters
  3.Oscillations Derived from Intracellular Feedback Regulation
  4.Oscillations Derived from Interactions between Different Species in Continuous Culture
  5.Oscillations Due to Synchronous Growth and Division
Bioprocess Development with Plant Cells
  MCE in Plants：Realities and Potentialities
  Plant Transformation for Studies on Metabolism and Physiology
  Improving Plants through Genetic Engineering
  Improving Plant Resistance to Chemicals，Pathogens and Stresses
  Improving Quality and Quantity of Plant Products
  Using Plant Genetic Engineering to Produce Heterologous Proteins
  Tools for the Manipulation and Transfolrmation of Plants
  Plant Metabolism：Matter and Energy Flows and the Prospects of MCA
  Metabolic Compartmentation in Plant Cells
  Carbon Assimilation.Partitioning and Allocation

  Carbon fixation in higher plants
  MCA Studies in Plants
  Regulation and Control：Starch Synthesi s.a Case Study
  Concluding Remarks
Cellular Engineering
  Outline
  The Global Functioning of Metabolic Networks
  The Nature of the Carbon Source Determines the Activation of
  Whole Blocks of Metabolic Pathways with Global Impact on
  Cellular Energetics
  Carbon Sources that Share Most Enzymes Required to TransfclITn
  the Substrates into Key Intermediary Metabolites under Similar
  Growth Rates.Bring About Similar Fluxes through the Main
  Amphibolic Pathways
  Interaction between Carbon and Nitrogen Regulatory Pathways
  in Scerevisiae
  Flux Redirection toward Catabolic(Fermention)or Anabolic
  (Carbohydrates)Products Mav Be Generated as a Result of
  AIteration in Redox and Phosphorylation Potentials
  Temperature—Dependent Expression of Certain Mutations
  Depend upon the Carbon Source
  There Seems to Exist a General PaRem of Control of the
  Intracellular Concen~ion of Metabolites
  Dependence of the Control of Giycolysis on the Genetic
  Background and the Physiological Status of Yeast in Chemostat
  Cultures
  Cellular Engineering
  Growth Rate.G1 Phase ofthe Cell Cycle.Production of Metabolites
  and Macromolecules as Targets for Cellular Engineering
  Catabolite Repression and Cell Cycle Regulation in Yeast
  Protein Production as a Function of Growth Rate
  The Selective Functioning of Whole Metabolic Pathways is
  Permissive for Differentiation
Bibliography
Index

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作者介绍

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