- 化学生物学导论(化学工业出版社十四五普通高等教育规划教材)(英文版)
- - 作者：编者:于洋|责编:王琰
  - 出版社：化学工业
  - ISBN：9787122497260
  - 出版日期：2026/02/01
  - 页数：289
- 售价：30

内容大纲
本书为英文版教材，系统介绍了化学生物学的基本概念、原理方法及应用。全书共分16章，首先概述了生物大分子的结构功能的相关基础知识及其化学合成方法。之后介绍了化学生物学的基本概念和重要方法，如生物正交性、大分子的序列－结构－功能关系、小分子－蛋白质相互作用等，并介绍化学生物学在生物催化和生物制药中的应用。
本书可作为化学化工和制药类高年级本科生和研究生教材。
作者介绍
目录
1  Introduction
  1.1  Overview of Chemical Biology
  1.2  Historical Context and Evolution of Chemical Biology
    1.2.1  Biological Effects of Chemicals
    1.2.2  Experiment against Vitalism
    1.2.3  Manipulating Biomacromolecules
    1.2.4  The Development of Synthetic Dyes and Chemotherapy
    1.2.5  20th Century and On
  1.3  Highlights of Contemporary Work
    1.3.1  Bio-orthogonal Chemistry
    1.3.2  Directed Evolution
    1.3.3  Display Technologies
    1.3.4  Deep Learning for Protein Structure Prediction
    1.3.5  Chemical Genetics
    1.3.6  Unnatural Amino Acids and Bases
    1.3.7  Synthetic Genomes
  Questions
  References
2  Chemical Principles in Biology
  2.1  Basic Chemistry of Biomolecules
    2.1.1  The Chemical Composition of Biomolecules
    2.1.2  Types of Biomolecules
  2.2  Chemical Bonds and Interactions in Biological Systems
    2.2.1  Covalent Bonds: The Backbone of Biomolecular Structure
    2.2.2  Non-Covalent Interactions and Biomolecular Structure
  2.3  Thermodynamics and Kinetics in Biochemical Reactions
    2.3.1  Thermodynamics: The Energetics of Biochemical Reactions
    2.3.2  Kinetics: The Rate of Biochemical Reactions
    2.3.3  The Interplay of Thermodynamics and Kinetics
  2.4  Conclusion
  Questions
  References
3  The Central Dogma of Molecular Biology
  3.1  Discovery
  3.2  Genetic Information Flow: Replication，Transcription，Translation
    3.2.1  Replication: Preserving Genetic Continuity
    3.2.2  Transcription: From DNA to RNA
    3.2.3  Translation: Synthesizing Proteins
    3.2.4  Integration of Genetic Information Flow
  3.3  Exceptions to the Central Dogma of Molecular Biology
    3.3.1  Reverse Transcription: RNA to DNA
    3.3.2  RNA Replication: RNA to RNA
    3.3.3  Perspective on Alternative Information Flow Pathways
  Questions
  References
4  Peptide and Protein
  4.1  Amino Acid
    4.1.1  Chemical Structure and Stereochemistry
    4.1.2  Side Chain Groups and Their Properties
    4.1.3  Post-Translational Modifications

  4.2  Hierarchical Structure of Proteins
    4.2.1  Primary Structure and Peptide
    4.2.2  Secondary Structure
    4.2.3  Tertiary Structure
    4.2.4  Quaternary Structure
    4.2.5  Protein Structure Determination
  4.3  Chemical Synthesis of Peptides
    4.3.1  Overview of Solid Phase Peptide Synthesis
    4.3.2  Key Steps in Solid Phase Peptide Synthesis
    4.3.3  Limitations of Solid Phase Peptide Synthesis
  4.4  Native Chemical Ligation
  4.5  Expressed Protein Ligation
  4.6  Comparison of Biosynthesis and Chemical Synthesis
  4.7  Conclusion
  Questions
  References
5  Nucleic Acid
  5.1  Introduction
  5.2  Chemical Composition and Structure of Nucleic Acids
  5.3  Biosynthesis of Nucleic Acids
    5.3.1  DNA Replication: Mechanism and Enzymatic Machinery
    5.3.2  RNA Transcription: Mechanism and Enzymatic Machinery
    5.3.3  Coordination and Regulation of Nucleic Acid Biosynthesis
  5.4  Polymerase Chain Reaction
  5.5  Chemical Synthesis of Nucleic Acids
    5.5.1  Principles of Chemical Nucleic Acid Synthesis
    5.5.2  Challenges and Advancements in Nucleic Acid Synthesis
    5.5.3  Enzymatic synthesis of Nucleic Acids
  5.6  Modifications and Labeling of Nucleic Acids
    5.6.1  Chemical Modifications of Nucleic Acids
    5.6.2  Labeling of Nucleic Acids
    5.6.3  Applications of Modified and Labeled Nucleic Acids
  5.7  Functional Versatility of Nucleic Acids
    5.7.1  Ribozymes: Catalytic RNA Molecules
    5.7.2  Riboswitches
    5.7.3  Aptamers and DNAzymes: Functional Nucleic Acid Developed in a Lab
    5.7.4  DNA as a Material: Structural and Functional Nanotechnology
  5.8  Applications of Nucleic Acids
    5.8.1  Nucleic Acids as Biosensors
    5.8.2  Nucleic Acids for Data Storage
    5.8.3  Nucleic Acids in Nanotechnology
  5.9  Conclusion
  Questions
  References
6  Carbohydrates
  6.1  Introduction to Carbohydrates
  6.2  Structure and Classification of Carbohydrates
    6.2.1  Monosaccharides: Structure and Stereochemistry
    6.2.2  Cyclic Structure of Monosaccharides
    6.2.3  Monosaccharide Derivatives

    6.2.4  Oligosaccharides and Polysaccharides
  6.3  Biosynthesis of Carbohydrates
    6.3.1  Glycogenesis: Synthesis of Glycogen
    6.3.2  Biosynthesis of Complex Carbohydrates: Glycosylation
  6.4  Chemical Synthesis of Carbohydrates
    6.4.1  Formation of Glycosidic Bonds
    6.4.2  Synthesis of Complex Polysaccharides
    6.4.3  Automated Chemical Synthesis of Polysaccharides
  6.5  Chemical Probes for Carbohydrate Metabolism
    6.5.1  Fluorescent Probes for Monitoring Carbohydrate Metabolism
    6.5.2  Activity-Based Probes for Profiling Glycosidase and Glycosyltransferase Activities
    6.5.3  Inhibitor-Based Probes for Modulating Carbohydrate Metabolism
    6.5.4  Probes for Imaging Carbohydrate Metabolism in Vivo
  6.6  Conclusion
  Questions
  References
7  Metals and Metalloprotein
  7.1  Introduction to Metal Ions and Their Biological Importance
  7.2  Essential Elements and Trace Metals
    7.2.1  Essential Elements
    7.2.2  Trace Metals
  7.3  Functional Role of Metals in Biology
    7.3.1  Role of Metals in Hydrolytic Reactions
    7.3.2  Metals in Electron Transfer
  7.4  Metal Catalyzed Oxygen Activation
    7.4.1  Oxygen Activation by Transition Metals
    7.4.2  Biological Implications of Metal-Mediated Oxygen Activation
  7.5  Iron and Heme Proteins
    7.5.1  Structure and Function of Heme
    7.5.2  Oxygen Transport: Hemoglobin and Myoglobin
    7.5.3  Electron Transfer: Cytochromes
    7.5.4  Catalysis: P450 Monooxygenases
  7.6  Conclusion
  Questions
  References
8  Bio-orthogonal Reaction
  8.1  Definition and Principles
  8.2  Bio-orthogonal Reactions
    8.2.1  The Staudinger Ligation
    8.2.2  Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC)
    8.2.3  Strain-Promoted Azide-Alkyne Cycloaddition
    8.2.4  Tetrazine Ligation
    8.2.5  Oxime and Hydrazone Formation
    8.2.6  Photoinduced Bio-orthogonal Reactions
    8.2.7  Metal-Mediated Bio-orthogonal Reactions
  8.3  Applications of Bio-orthogonal Chemistry
    8.3.1  Molecular Imaging and Labeling
    8.3.2  Drug Delivery and Therapeutics
    8.3.3  In Vivo Chemical Biology
  8.4  Conclusion

  Questions
  References
9  Orthogonality in Biological Systems
  9.1  Semantic and Alphabetic Orthogonality
  9.2  Orthogonality in Translation Systems
    9.2.1  Orthogonal tRNA and Aminoacyl-tRNA Synthetase Pairs
    9.2.2  Orthogonal Ribosomes
  9.3  Orthogonal Replication and Transcription System
    9.3.1  Orthogonal DNA Replication Systems
    9.3.2  Design and Implementation of Orthogonal Transcription Systems
  9.4  Genetic Code Expansion
    9.4.1  Reassigning Stop Codons
    9.4.2  Quadruplet Codon Systems
    9.4.3  Genome Redesign
    9.4.4  Applications of Unnatural Amino Acids
  9.5  Mirror-Image System
  9.6  Expansion of the Genetic Alphabet
  9.7  Conclusion
  Questions
  References
10  Sequencing and Biological Databases
  10.1  Nucleic Acid Sequencing and the Omics
    10.1.1  Sanger Sequencing: The Foundation of Genomics
    10.1.2  The Human Genome Project: A Milestone in Genomic Research
    10.1.3  Next-Generation Sequencing: High-Throughput Genomics
    10.1.4  The Third-Generation Sequencing: Long Reads for Genomics Study
    10.1.5  Metagenomics: Exploring the Microbial World
  10.2  Protein Sequencing
    10.2.1  Historical Context and Edman Degradation
    10.2.2  Mass Spectrometry-Based Protein Sequencing
    10.2.3  Nanopore Sequencing of Proteins
  10.3  Biological Databases
    10.3.1  GenBank: A Comprehensive Nucleotide Sequence Database
    10.3.2  UniProt: The Universal Protein Resource
    10.3.3  PDB: The Protein Data Bank
    10.3.4  KEGG: Kyoto Encyclopedia of Genes and Genomes
    10.3.5  BRENDA: The Comprehensive Enzyme Information System
    10.3.6  Databases in the AI era
  Questions
  References
11  Protein Structure Prediction
  11.1  Protein Folding
  11.2  Computational Methods for Protein Structure Prediction
    11.2.1  Molecular Dynamics Simulations
    11.2.2  Homology Modeling and Threading
    11.2.3  Rosetta
    11.2.4  Critical Assessment of Structure Prediction (CASP)
  11.3  AI Methods in Protein Structure Prediction
    11.3.1  AlphaFold2: A Landmark Achievement
    11.3.2  Protein Language Models and Structure Prediction

    11.3.3  Other Structure Prediction Methods and Recent Advances
  11.4  Impact of AI-Based Protein Structure Prediction
    11.4.1  Establishment of Structural Databases
    11.4.2  Transformation from Sequence-Based to Structure-Based Methods
  11.5  Conclusion
  Questions
  References
12  Molecular Evolution and Directed Evolution
  12.1  Natural Evolution
    12.1.1  The Principles of Natural Evolution
    12.1.2  From Natural to Directed Evolution
  12.2  Evolution of Biomacromolecules
    12.2.1  Phylogenetic Tree: Tracing Evolutionary Relationships
    12.2.2  Information from Molecular Evolution and Rich Sequence Data
    12.2.3  Ancestral Sequence Reconstruction
    12.2.4  Amino Acid Coevolution
    12.2.5  Evolution as a Searching Algorithm
  12.3  Directed Evolution: Accelerating Natural Processes
    12.3.1  Methods for Introducing Variation
    12.3.2  Amplification and Linking of Gene Libraries
    12.3.3  Screening and Selection
  12.4  AI-Assisted Directed Evolution
    12.4.1  Machine Learning in Directed Evolution
    12.4.2  Protein Language Models
  12.5  In Vivo Directed Evolution
    12.5.1  Principles of In Vivo Directed Evolution
    12.5.2  Examples of In Vivo Directed Evolution Systems
  12.6  Conclusion
  Questions
  References
13  Protein Computational Design
  13.1  Protein Sequence Space and Fitness Landscape
    13.1.1  Exploring the Fitness Landscape
    13.1.2  Schemes of Computational Design
  13.2  Design Strategies: De Novo vs. Redesign
    13.2.1  De Novo Protein Design
    13.2.2  Protein Redesign and Mutation
    13.2.3  Biochemical and Structural Biology Knowledge in Protein Design
  13.3  Protein Design: An Overview
    13.3.1  Historical Context
    13.3.2  Peptide Design
    13.3.3  Rosetta in Protein Design
  13.4  Deep Learning-Based Methods in Computational Protein Design
    13.4.1  The Inverse Folding Problem and Sequence Design
    13.4.2  Backbone Design
    13.4.3  Sequence-Structure Co-Design
    13.4.4  Strategies toward Designing Function
  13.5  Conclusion
    13.5.1  Interplay of Experiment and Computation
    13.5.2  Database for Training

    13.5.3  Integration with Directed Evolution
    13.5.4  Multimodal Design
  Questions
  References
14  Chemical Genetics
  14.1  Classical Genetics
    14.1.1  Forward Genetics
    14.1.2  Reverse Genetics
  14.2  Protein-Small Molecule Interactions
  14.3  Principles of Chemical Genetics
    14.3.1  Forward Chemical Genetics
    14.3.2  Reverse Chemical Genetics
    14.3.3  Methodologies in Chemical Genetics
  14.4  Chemical Genetics in Drug Discovery
  Questions
  References
15  Biocatalysis
  15.1  Chemo-enzymatic Catalysis
  15.2  Artificial Enzymes
  15.3  Photocatalysis
    15.3.1  Strategies for Combining Biocatalysis and Photocatalysis
    15.3.2  Repurposing Natural Photoenzymes
    15.3.3  Elucidating New Photoreactivity Within Cofactor-Dependent Enzymes
    15.3.4  Synergistic Combination of External Photocatalysis and Enzymes
    15.3.5  Construction of Artificial Photoenzymes
  15.4  Biocatalysis with Functional Materials
  15.5  Conclusion
  Questions
  References
16  Biopharmaceuticals
  16.1  Introduction to Biopharmaceuticals
  16.2  Categories of Biopharmaceuticals
    16.2.1  Biocatalysis and Biotransformation Products
    16.2.2  Biomacromolecules
    16.2.3  Cells and Cell Components
  16.3  Case Studies in Biopharmaceuticals
    16.3.1  Insulin as a Pioneering Biopharmaceutical
    16.3.2  Biocatalysis in the Synthesis of Sitagliptin
    16.3.3  Monoclonal Antibodies Engineering
    16.3.4  CAR-T Therapy: A New Frontier in Cancer Treatment
  16.4  Conclusion
  Questions
  References

内容大纲

作者介绍

目录

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